Sciences de la Nutrition

HDR en Sciences de la nutrition, 2017

Nutrition

Biotechnologie Animale

Procéde agro-alimentaire

Physiologie animale

1. Hamden, K., Ali Boujibiha, M., Ben Abdeljelil, N., Njima, M., Selmi, B., & Achour, L. (2019). Phytoestrogens inhibit key-enzymes linked to obesity, type 2 diabetes and liver-kidney toxicity in high fructose-fat diet in mice. Archives of physiology and biochemistry, 1-7.
2. Afsa S, Hamden K, Lara Martin  PA & Ben Mansour H (2019). Occurrence of 40 pharmaceutically active compounds in hospital and urban wastewaters and their contribution to Mahdia coastal seawater contamination. Environmental Science and Pollution Research
3. Cherif, B., Triki, H., Sahnoun, S., Hamden, K., Sallemi, A., Charfi, S., & Lassoued, S. (2019). Imipenem toxicity in male reproductive organs as a result of inflammatory microenvironment and oxidative stress in germinal cells. Toxicology, 416, 44-53.
4. Hamden, K., Boujibiha, M. A., Abdeljelil, N. b., Njima, M., & Achour, L. (2018). Inhibitory Effect of fermented pectin on Digestive Enzymes Related to obesity, Hyperlipidemia and hyperglycaemia; and Liver-Kidney tissues toxicities. Bioactive carbohydrates and dietary fibre.
5. Zouari, R., Hamden, K., El Feki, A., Chaabouni, K., Makni-Ayadi, F., Sallemi, F., Ellouze-Chaabouni, S., & Ghribi-Aydi, D. (2017). Evaluation of Bacillus subtilis SPB1 biosurfactant effects on hyperglycemia, angiotensin I-converting enzyme (ACE) activity and kidney function in rats fed on high-fat–high-fructose diet. Archives of physiology and biochemistry, 123(2), 112-120.
6. Hamden K, Boujibiha MA, ben Abdeljelil N, Njima M Achour, L. Inhibitory Effect of fermented pectin on key metabolic enzymes associated with diabetes, obesity; and Liver-Kidney tissues toxicities. https://doi.org/10.1016/j.bcdf.2018.07.002 Received 14 March 2018; Accepted 25 July 2018
7. Hamden K, Ali Boujibiha M, Ben Abdeljelil N, Njima M, Selmi B, Achour L. Phytoestrogens inhibit key-enzymes linked to obesity, type 2 diabetes and liver-kidney toxicity in high fructose-fat diet in mice. Arch Physiol Biochem. 2018 Jun 14:1-7. doi: 10.1080/13813455.2018.1479427.
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9. Hamden K, Khlifi S, ben Jemaa H, ben Ahmed H, Aouidet A, Achour L (2017) Inhibitory Effects of Phytoestrogens on Lipase, Insulin Resistance and Liver-kidney Toxicity in High Fructose-Fat Diet Induced Obesity-type 2 Diabetes in Mice. Journal of Food and Nutrition Research, 2017, Vol. 5, No. x, xx; DOI:10.12691/jfnr-5-x-x (IF 2017:  1.62).
10. Hamden K, Keskes H, Elgomdi O, Feki A & Alouche N (2017) Modulatory Effect of an Isolated Triglyceride from Fenugreek Seed Oil on of α-Amylase, Lipase and ACE Activities, Liver-Kidney Functions and Metabolic Disorders of Diabetic Rats. Journal of Oleo Science 66:633-645 (IF 2017:  1.26).
11. Hamden K, Mnafgui K, Amri Z, Aloulou A & Elfeki A (2012) Inhibition of key digestive enzymes related to diabetes and hyperlipidemia and protection of liver-kidney functions by trigonelline in diabetic rats. Scientia pharmaceutica 81:233-246 (IF 2014:  1.64).
12. Hamden K, Bengara A, Amri Z & Elfeki A (2013) Experimental diabetes treated with trigonelline: effect on key enzymes related to diabetes and hypertension, β-cell and liver function. Molecular and cellular biochemistry 381:85-94 (IF 2013:  2.76).
13. Hamden K & Elfeki A (2012) Inhibitory potential of dietary fiber on key enzymes of carbohydrate-lipid digestion and absorption in pancreas of diabetes rats. Diabetes/metabolism: Research & Reviews 28:103 (IF 2012:   3.75).
14. Hamden K, Keskes H, Belhaj S, Mnafgui K & Allouche N (2011) Inhibitory potential of omega-3 fatty and fenugreek essential oil on key enzymes of carbohydrate-digestion and hypertension in diabetes rats. Lipids in health and disease 10:226 (IF 2011:  3.28).
15. Hamden K, Jaouadi B, Zaraî N, Rebai T, Carreau S & Elfeki A (2011) Inhibitory effects of estrogens on digestive enzymes, insulin deficiency, and pancreas toxicity in diabetic rats. Journal of physiology and biochemistry 67:121-128 (IF 2011:  2.43).
16. Hamden K, Jaouadi B, Carreau S, Aouidet A & Elfeki A (2011) Therapeutic effects of soy isoflavones on α-amylase activity, insulin deficiency, liver–kidney function and metabolic disorders in diabetic rats. Natural product research 25:244-255 (IF 2011:  0.919).
17. Hamden K, Mohamed Ali Boujibiha,Nouha ben Abdeljelil, Manel Njima, Fadwa        Neffati, Mohamed Fadhel Najjar, Wafa ElAyeb, Lotfi Achour. Fermented Soy Milk by Kefir prevents and ameliorates obesity, type 2 diabetes, Hyperlipidemia and Liver-Kidney toxicities in HFFD-rats. J functional Food, Soumis (IF 2017:  4.43).
18. Hamden K, Mohamed Ali Boujibiha,Nouha ben Abdeljelil, Manel Njima, Fadwa        Neffati, Mohamed Fadhel Najjar, Wafa ElAyeb, Lotfi Achour. Inhibitory Effect of fermented pectin on Digestive Enzymes Related to obesity, Hyperlipidemia and hyperglycaemia; and Liver-Kidney tissues toxicities. Applied Physiology, Nutrition and Metabolism, Soumis (IF 2017:  1.9).
19. K Hamden, B Jaouadi, T Salami, S Carreau, S Bejar, A Elfeki. Inhibitory Effect of Fenugreek Galactomannan on Digestive Enzymes Related to Diabetes, Hyperlipidemia and Liver-Kidney Dysfunctions. Biotechnology and Bioprocess Engineering 15, 407-413, 2010 (IF 2010:  1.16).
20. K Hamden, N Allouche, M Damak, S Carreau, A Elfeki. Potential protective effect of hydroxytyrosol against glucose-induced toxicity in spermatozoa in vitro. Asia Life Sciences 19(2), 333-345, 2010 (IF 2010: 0.13).
21. K Hamden, B Jaouadi, S Carreau, A Aouidet, S El-Fazaa, N Gharbi,, A Elfeki: Potential protective effect on key steroidogenesis and metabolic enzymes and sperm abnormalities by fenugreek steroids in testis and epididymis of surviving diabetic rats. Archives of physiology and biochemistry 116 146-155, 2010 (IF 2010:  0.56).
22. K Hamden, B Jaouadi, T Salami, S Carreau, S Bejar, A Elfeki. Modulatory Effect of Fenugreek Saponins on the Activities of Intestinal and Hepatic Disaccharidase and Glycogen and Liver Function of Diabetic Rats. Biotechnology and Bioprocess Engineering 15: 745-753 (2010) (IF 2010:  1.16).
23. K Hamden, S Carreau, A Elfeki. Inhibitory effects of Zinc on hyperglycaemia and metabolic disorders in the liver of alloxan-induced diabetic rats. Asian Biomedicine 2009;3: 745-750 (IF 2009:  0.11).
24. K Hamden, S Carreau, F Ayadi, H Masmoudi, EL Abdelfattah. Inhibitory effect of estrogens, phytoestrogens and caloric restriction from oxidative stress and hepato-toxicity in aged rat. Biomedical Enviromental Sciences 22: 381-387, 2009 (IF 2009:  0.95).
25. K Hamden, S Carreau, F Ellouz, H Masmoudi, EI Feki. Improvement effect of green tea on hepatic dysfunction, lipid peroxidation and antioxidant defence depletion induced by cadmium. African Journal of Biotechnology 8 (17), 2009 (IF 2009:  0.82).
26. K Hamden, N Allouche, M Damak, A Elfeki. Hypoglycemic and antioxidant effects of phenolic extracts and purified hydroxytyrosol from olive mill waste in vitro and in rats. Chemico-Biological Interactions, 180: 421-432, 2009 (IF 2009:  2.75).
27. K Hamden, S Carreau, K Jamoussi, F Ayadi, F Garmazi, A Elfeki. Dietary Nigella sativa and Peganum harmala Oils Reverses Hyperglycaemia, Hepatotoxicity, and Metabolism in Rats. Food Sci. Biotechnol. 2009 ; 180 : 421–432 (IF 2009:  0.69).
28. K Hamden, MA Boujbiha, H Masmoudi, FM Ayadi, K Jamoussi, A Elfeki. Combined vitamins (C&E) and insulin improve oxidative stress and pancreatic and hepatic injury in alloxan diabetic rats. Biomed. Pharmacother 63: 95-99, 2009 (IF 2009:  2.11).
29. K Hamden, F Ayadi, K Jamoussi, H Masmoudi, A Elfeki. Therapeutic effect of phytoecdysteroids rich extract from Ajuga iva on liver, kidney and pancreas function. Biofactors 33: 1-12, 2009 (IF 2009:  1.62).
30. K Hamden, N Allouche, M Damak, S Carreau, A Elfeki. Inhibitory action of hydroxytyrosol from glucose-induced insulin deficient and pancreas and liver toxicity in vitro. Current Trends in Biotechnology and Pharmacy 3 (4), 352-361, 2009 (IF 2009:  0.37).
31. K Hamden, S Carreau, K Jamoussi, S Miladi, S Lajmi, D Aloulou, F Ayadi,, S miladi, S Lajmi, D Aloulou, A Elfeki. Title：1α,25dihydroxyvitaminD3: Therapeutic and preventive effects against oxidative stress and hepatic, pancreatic and renal injury in diabetic rats. Journal of Nutritional Science and Vitaminology 55: 215-222, 2009 (IF 2009: 1.33).
32. K Hamden, D Silandre, C Delalande, A ElFeki, S Carreau. Protective effects of estrogens and caloric restriction during aging on various rat testis parameters. Asian J Androl10:!177-187,2008 (IF 2008: 2.60).
33. K Hamden, D Silandre, C Delalande, A ElFeki, S Carreau. Age-related decrease in aromatase and estrogen receptor (ERα and ERβ) expression in rat testes: protective effect of low caloric diets. Asian J Androl 10:!177-187, 2008 (IF 2008: 2.60).
34. K Hamden, S Carreau, K Jamoussi, F Ayadi, F Garmazi, N Mezgenni, A Elfeki. Inhibitory effects of 1α, 25dihydroxyvitamin D3 and Ajuga iva extract on oxidative stress, toxicity and hypo-fertility in diabetic rat testes. Journal of physiology and biochemistry 64 (3), 231-239, 2008 (IF 2008: 1.48).
35. K Hamden, S Carreau, MA Boujbiha, S Lajmi, D Aloulou, D Kchaou, A Elfeki. Hyperglycaemia, stress oxidant, liver dysfunction and histological changes in diabetic male rat pancreas and liver: Protective effect of 17β-estradiol. Steroids 73 (5), 495-501, 2008 (IF 2008: 3.12).
36. K Hamden, A Elfeki, F Ayadi, K Jamoussi, H Masmoudi. Therapeutic effect of phytoecdysteroids rich extract from Ajuga iva on alloxan induced diabetic rats liver, kidney and pancreas. Biofactors 33 (3), 165-175, 2008 (IF 2008: 1.52).
37. K Hamden, S Carreau, F Ayadi Marki, H Masmoudi, A El Feki. Positive effects of green tea on hepatic dysfunction, lipid peroxidation and antioxidant defence depletion induced by cadmium. Biological research 41 (3), 331-339, 2008 (IF 2008: 1.28).
38. K Hamden, S Carreau, F Ellouz, H Masmoudi, A El Feki. Protective effect of 17β-estradiol on oxidative stress and liver dysfunction in aged male rats. Journal of physiology and biochemistry 63 (3), 195-201, 2007 (IF 2007: 1.85).
39. K Hamden, H Masmoudi, F Ellouz, A ElFeki, S Carreau. Protective effects of Peganum harmala extracts on thiourea-induced diseases in adult male rat. Journal of environmental biology 29 (1), 73, 2007 (IF 2007: 0.67).
40. Jdir H, Hamden K, Zouari N, Fakhfakh N, Kolsi RBA & Zouari S (2017) The cruciferous Diplotaxis simplex: Phytochemistry analysis and its protective effect on liver and kidney toxicities, and lipid profile disorders in alloxan-induced diabetic rats. Lipids in health and disease 16:100 (IF 2017:  2.073).
41. Zouari R, Hamden K, El Feki A, Chaabouni K, Makni-Ayadi F, Sallemi F, Ellouze-Chaabouni S & Ghribi-Aydi D (2017) Evaluation of Bacillus subtilis SPB1 biosurfactant effects on hyperglycemia, angiotensin I-converting enzyme (ACE) activity and kidney function in rats fed on high-fat–high-fructose diet. Archives of physiology and biochemistry 123:112-120 (IF 2016:  0.09).
42. Zouari R, Hamden K, El Feki A, Chaabouni K, Makni-Ayadi F, Kallel C, Sallemi F, Ellouze-Chaabouni S & Ghribi-Aydi D (2016) Protective and curative effects of Bacillus subtilis SPB1 biosurfactant on high-fat-high-fructose diet induced hyperlipidemia, hypertriglyceridemia and deterioration of liver function in rats. Biomedicine & pharmacotherapy 84:323-329 (IF 2016:  1.86).
43. Zouari R, Hamden K, El Feki A, Chaabouni K, Ayedi F, Ellouze-Chaabouni S & Ghribi-Aydi D (2016) Effet de l’administration du biosurfactant de Bacillus subtilis SPB1 sur l’activité de l’enzyme de conversion de l’angiotensine dans le sérum et le cœur des rats rendus obèses par un régime riche en fructose et en graisses de mouton. Nutrition Clinique et Métabolisme 30:282-283 (IF 2016:  1.86).
44. Bejar W, Hamden K, Salah RB & Chouayekh H (2013) Lactobacillus plantarum TN627 significantly reduces complications of alloxan-induced diabetes in rats. Anaerobe 24:4-11(IF 2013: 3.12).
45. Hamzaoui S, Hamden K, Ben Salem A, Mourer M, Regnouf‐De‐Vains JB & Kossentini M (2013) Synthesis and Evaluation of 1, ω‐Bis (1, 2, 3, 5‐thiatriazol‐5‐yl) alkanes as In Vitro and In Vivo α‐Amylase and Lipase Inhibitors. Archiv der Pharmazie 346:321-329 (IF 2013:  1.94).
46. Aloulou A, Hamden K, Elloumi D, Ali MB, Hargafi K, Jaouadi B, Ayadi F, Elfeki A & Ammar E (2012) Hypoglycemic and antilipidemic properties of kombucha tea in alloxan-induced diabetic rats. BMC complementary and alternative medicine 12:63(IF 2012:  4.22).
47. K Mnafgui, K Hamden, H Ben Salah, M Kchaou, M Nasri, S Slama, F Derbali, N Allouche, A Elfeki. Inhibitory Activities of Zygophyllum album: A Natural Weight-Lowering Plant on Key Enzymes in High-Fat Diet-Fed Rats. Evidence-Based Complementary and Alternative Medicine 9, 1-9, 2012 (IF 2012:  2.52).
48. I Khlif, K Hamden, M Damak, N Allouche. A new triterpene from Olea europea stem with antidiabetic activity. Chemistry of Natural Compounds, 1-4, 2012 (IF 2012:  0.42).
49. Z Ghlissi, K Hamden, M Saoudi, Z Sahnoun, KM Zeghal, A El Feki, A Hakim. Effect of Nigella sativa seeds on reproductive system of male diabetic rats. African Journal of Pharmacy and Pharmacology 1444-1450 63, 2012 (IF 2012:  0.65).
50. A Aloulou, K Hamden, D Elloumi, MB Ali, K Hargafi, B Jaouadi, F Ayadi, A El Feki, E Ammar. Hypoglycemic and antilipidemic properties of kombucha tea in alloxan-induced diabetic rats. BMC Complementary and Alternative Medicine 12:63, 2012 (IF 2012:  4.22).
51. MAM Boujbiha, K Hamden, F Guermazi, A Bouslama, A Omezzine, A ElFeki. Impairment of spermatogenesis in rats by mercuric chloride: involvement of low 17β-estradiol level in induction of acute oxidative stress. Biological trace element research 142 3 598-610, 2011 (IF 2011:  3.36).
52. I Dahech, KS Belghith, K Hamden, A Feki, H Belghith, H Mejdoub. Oral administration of levan polysaccharide reduces the alloxan-induced oxidative stress in rats. International journal of biological macromolecules 49 (5), 942-947, 2011 (IF 2011:  2.36).
53. I Dahech, KS Belghith, K Hamden, A Feki, H Belghith, H Mejdoub. Antidiabetic activity of levan polysaccharide in alloxan-induced diabetic rats. International journal of biological macromolecules 49 (4), 742-746, 2011 (IF 2011:  2.36).
54. B Gargouri, R ben Mansour, MM Jmal, RN Boujelben, N Allouch, S Lassoued, K Hamden. Hydroxytyrosol supplementation inhibits oxidative DNA damage, suppresses protein-lipid oxidation and modulates antioxidant enzymes in human peripheral blood lymphocytes. Journal of Medicinal Plants Research 5 (19), 4863-4869, 2011 (IF 2011:  1.64).
55. K Rouissi, B Hamrita, S Kouidi, Y Messai, B Jaouadi, K Hamden, I Medimegh, S Ouerhani, M Cherif, AB Elgaaied. In Vivo Prevention of Bladder Urotoxicity Purified Hydroxytyrosol Ameliorates Urotoxic Effects of Cyclophosphamide and Buthionine Sulfoximine in Mice. International journal of toxicology 30 (4), 419-427, 2011 (IF 2011:   0.03).
56. KS Belghith, I Dahech, K Hamden, A Feki, H Mejdoub, H Belghith. Hypolipidemic effect of diet supplementation with bacterial levan in cholesterol-fed rats. International journal of biological macromolecules 50 (4), 1070-1074, 2012 (IF 2012:  1.83).
57. K Mnafgui, F Kaanich, A Derbali, K Hamden, F Derbali, S Slama, N Allouche, A Elfeki. Inhibition of key enzymes related to diabetes and hypertension by Eugenol in vitro and in alloxan-induced diabetic rats. Archives of physiology and biochemistry 119 (5), 225-233, 2013 (IF 2013: 1.09).
58. RB Salah, I Trabelsi, K Hamden, H Chouayekh, S Bejar. Lactobacillus plantarum TN8 exhibits protective effects on lipid, hepatic and renal profiles in obese rat. Anaerobe 23, 55-61, 2013 (IF 2013: 3.12).
59. I Dahech, B Harrabi, K Hamden, A Feki, H Mejdoub, H Belghith. Antioxidant effect of nondigestible levan and its impact on cardiovascular disease and atherosclerosis. International journal of biological macromolecules 58, 281-286, 2013 (IF 2013: 1.91).
60. S BelHadj, O Hentati, A Elfeki, K Hamden. Inhibitory activities of Ulva lactuca polysaccharides on digestive enzymes related to diabetes and obesity. Archives of physiology and biochemistry 119 (2), 81-87, 2013 (IF 2013:  0.90).
61. N Ktari, K Mnafgui, R Nasri, K Hamden, I Bkhairia, AB Hadj, T Boudaouara, A Elfeki, M Nasri. Hypoglycemic and hypolipidemic effects of protein hydrolysates from zebra blenny (Salaria basilisca) in alloxan-induced diabetic rats. Food & function 4 (11), 1691-1699, 2013 (IF 2013:   2.58).
62. H Keskes, K Mnafgui, K Hamden, M Damak, A El Feki, N Allouche. In vitro anti-diabetic, anti-obesity and antioxidant proprieties of Juniperus phoenicea L. leaves from Tunisia. Asian Pacific Journal of Tropical Biomedicine 4, S649-S655, 2014 (IF 2014:  2.60).
63. N Ktari, R Nasri, K Mnafgui, K Hamden, O Belguith, T Boudaouara, A El Feki, M Nasri. Antioxidative and ACE inhibitory activities of protein hydrolysates from zebra blenny (Salaria basilisca) in alloxan-induced diabetic rats. Process Biochemistry 49 (5), 890-897, 2014 (IF 2014:  3.69).
64. K Mnafgui, M Kchaou, K Hamden, F Derbali, S Slama, M Nasri, HB Salah, N Allouche, A Elfeki. Inhibition of carbohydrate and lipid digestive enzymes activities by Zygophyllum album extracts: Effect on blood and pancreas inflammatory biomarkers in alloxan-induced Diabetic rats. Journal of physiology and biochemistry 70 (1), 93-106, 2014 (IF 2014:  2.20).
65. R Nasri, O Abdelhedi, I Jemil, I Daoued, K Hamden, C Kallel, A Elfeki, M Lamri-Senhadji, A Boualga, M Nasri, M Karra-Châabouni. Ameliorating effects of goby fish protein hydrolysates on high-fat-high-fructose diet-induced hyperglycemia, oxidative stress and deterioration of kidney function in rats. Chemico-biological interactions 242, 71-80, 2015 (IF 2015:  2.52).
66. R Zouari, R Ben Abdallah Kolsi, K Hamden, AE Feki, K Chaabouni. Assessment of the antidiabetic and antilipidemic properties of bacillus subtilis spb1 biosurfactant in alloxan‐induced diabetic rats. Peptide Science Peptide Science 104 (6), 764-774, 2015 (IF 2015: 1.95).
67. S Hamzaoui, B Ben Salah, K Hamden, A Rekik, M Kossentini. Synthesis and Evaluation of New Bis-1, 3, 4, 2-triazaphospholinoalkane Derivatives as In Vitro α‐Amylase and Lipase Inhibitors. Archiv der Pharmazie 348 (3), 188-193, 2015 (IF 2015:  2.17).

68. I Trabelsi, N Ktari, S Ben Slima, K Hamden, R Ben Salah. Effect of a probiotic Lactobacillus plantarum TN8 strain on trinitrobenzene sulphonic acid‐induced colitis in rats. Journal of Animal Physiology and Animal Nutrition, in press (IF 2016:  1.14).
69. K Hamden, H Masmoudi, S Carreau, A Elfeki. Immunomodulatory, β-cell, and neuroprotective actions of fenugreek oil from alloxan-induced diabetes. Immunopharmacology and Immunotoxicology 1–9, 2010 (IF 2010: 1.06).
70. MA Boujbiha, K Hamden, F Guermazi, A Bouslama, A Omezzine, A Kammoun, A ElFeki. Testicular toxicity in mercuric chloride treated rats: Association with oxidative stress. Reproductive toxicology 28 (1), 81-89, 2009 (IF 2009:  3.01).
71. FB Abdallah, K Hamden, I Galeraud‐Denis, A El Feki, L Keskes‐Ammar. An in vitro study on reproductive toxicology of Deltamethrin on rat spermatozoa. Andrologia  41: 1–6, 2009 (IF 2009:  1.83).
72. S Carreau, D Silandre, S Bourguiba, K Hamden, L Said, S Lambard, ... Estrogens and male reproduction: a new concept. Brazilian Journal of Medical and Biological Research 40 (6), 761-768, 2007 (IF 2007: 0.60).

Depuis 2015

• Member of the scientific council 2017-2020
• Member of the Quality Committee 2017-2020
• Member of the 2017-2020 Exam Committee
• Member of the Discipline Committee 2017-2020
• Coordinator of the professional master's degree in Waste Management, Treatment and Recovery
• (GTVD)
• Member of the organization of the Tunisian Nutrition Association
• Member of the recruitment committee of technicians for the Tunisian Ministry of Public Health (2009).